Post-doctoral position at I2MC-Toulouse (France) : Theralymph : An innovative therapy for lymphedema
A postdoctoral position, with salary funded for three years is available in the team “Molecular regulations of (lymph)angiogenic growth factors in vascular diseases” of the Institute of Metabolic and Cardiovascular Diseases of Toulouse (team 13, I2MC/INSERM U1048) directed by Dr Barbara GARMY-SUSINI. The candidate will determine key regulators in a lymphatic unmet disease called lymphedema that affects more than 200 million people worldwide, to establish gene therapy based clinical trial starting in 2024. The work will be a part of the THERALYMPH Horizon 2020 program including 6 European countries, 1 Biotech and Toulouse Rangueil hospital (https://theralymph-europe.eu/).
We seek a highly motivated scientist that hold a PhD in biology, with a strong background in mice physiopathology and skills in cellular and molecular biology. Good track record, communication, technical and organizational skills are expected.
The position is for 3 years, available immediately. The application should contain a motivation letter, CV and contact details of 2 referees.
The candidate will investigate multiple therapy to restore the lymphatic function in lymphedematous limb after breast cancer surgery. The objectives will be to 1/describe the physiopathology of lymphedema 2/ To identify therapeutic targets for lymphedema, 3/ To validate therapeutic targets in preclinic models of lymphedema. This project will lead to a Phase I/II gene therapy clinical trial on patients who developed lymphedema after breast cancer using lentiflash vectors.
The Host Institute
The Institute of Cardiovascular and Metabolic Diseases (I2MC) of Toulouse is composed of 280 people including scientists, MD-PhD, engineers, technicians, students, postdocs and administrators. The research activity focuses on metabolic and cardiovascular diseases. The main feature of I2MC is the gathering of basic scientists together with clinicians working on metabolic risk factors (obesity, diabetes and dyslipidemia) and their cardiovascular complications (thrombosis, atherosclerosis, cardiac and renal failure). The I2MC is equipped with the most recent technological tools and platforms including fully automated animal facility, flow cytometry platform, imaging platform, single cell sorting and next generation sequencing platform (http://www.i2mc.inserm.fr/index.php/fr/).
. Audrey Zamora1, Melinda Alves1, Charlotte Chollet2, Nicole Therville3, Tiffany Fougeray4, Florence Tatin1, Camille Franchet5, Anne Gomez-Brouchet5, Charlotte Vaysse2, Laurent O. Martinez1, Souad Najib1, Julie Guillermet-Guibert3, Eric Lacazette1, Anne-Catherine Prats1, Barbara Garmy-Susini1. « Paclitaxel induces lymphatic endothelial cells autophagy to promote metastasis ». Cell Death & Disease 2019 Dec 20;10(12):956
. Morfoisse F. PhD1*, Tatin F. PhD 1*, Chapût B. MD2, Therville N.3, Vaysse C. MD 4, Métivier R. PhD 5, Malloizel-Delaunay J. MD 6, Pujol F. 1, Godet AC. 1, De Toni F. PhD1, Boudou, F. 1, Grenier k. 7, Dubuc D. 7, Lacazette E. PhD 1, Prats AC. PhD 1, Guillermet-Guibert J. PhD 3, Lenfant F. PhD 1, Garmy-Susini B. PhD1#“Lymphatic vasculature requires estrogen receptor alpha signaling to protect from lymphedema”. Arterioscler Thromb Vasc Biol. 2018 Apr 12.
.Florence Tatin1, Edith Renaud-Gabardos1, Fransky Hantelys1, Anne-Claire Godet1, Francoise Pujol1, Florent Morfoisse2, Denis Calise3, Fanny Viars4, Philippe Valet1, Bernard Masri1, Anne-Catherine Prats1 and Barbara Garmy-Susini1 « Apelin modulates pathological remodeling of lymphatic endothelium after myocardial infarction. » JCI Insight June 2017
. Morfoisse F, Tatin F, Hantelys F, Adoue A, Helfer AC, Cassant-Sourdy S, Pujol F, Gomez-Brouchet A, Ligat L, Lopez F, Pyronnet S, Courty J, Guillermet-Guibert J, Marzi S, Schneider RJ, Prats AC, Garmy-Susini BH. « Nucleolin promotes heat shock-associated translation of VEGF-D to promote tumor lymphangiogenesis. » Cancer Res. 2016 Jun 8.
. Florent Morfoisse, Anna Kuchnio, Clement Frainay, Anne Gomez-Brouchet, Marie-Bernadette Delisle, Stefano Marzi, Anne-Catherine Helfer, Fransky Hantelys, Francoise Pujol, Julie Guillermet-Guibert, Corinne Bousquet, Mieke Dewerchin, Stephane Pyronnet, Anne-Catherine Prats, Peter Carmeliet, Barbara Garmy-Susini. “ Hypoxia induces VEGF-C expression in metastatic tumor cells via a HIF-1a-independent translation-mediated mechanism”. Cell Reports. 2014 Jan 16.
. Garmy-Susini B, Avraamides CJ, Desgrosellier JS, Schmid MC, Foubert P, Ellies LG, Lowy AM, Blair SL, Vandenberg SR, Datnow B, Wang HY, Cheresh DA, Varner J. « PI3Kα activates integrin α4β1 to establish a metastatic niche in lymph nodes. » Proc Natl Acad Sci U S A. 2013 May 13.
. Avraamides CJ, Garmy-Susini B, Varner JA. Integrins in angiogenesis and lymphangiogenesis. Nat Rev Cancer. 2008 Aug;8(8):604-17.
Contact : Dr Barbara GARMY-SUSINI Tel. : +33(0) 5 31 22 40 87 ; Email : firstname.lastname@example.org