Publications
Lymphatic malformations: mechanistic insights and evolving therapeutic frontiers
Milena Petkova, … , Ingvar Ferby, Taija Mäkinen
Pathogenic variants in HGF give rise to childhood-to-late onset primary lymphoedema by loss of function
Murat Alpaslan, Elodie Fastré, Sandrine Mestre, Arie van Haeringen, Gabriela M. Repetto, Kathelijn Keymolen, Laurence M. Boon, Florence Belva, Guido Giacalone, Nicole Revencu, Yves Sznajer, Katie Riches, Vaughan Keeley, Sahar Mansour, Kristiana Gordon, Silvia Martin-Almedina, Sara Dobbins, Pia Ostergaard, Isabelle Quere, Pascal Brouillard, Miikka Vikkula
Epilepsy with faint capillary malformation or reticulated telangiectasia associated with mosaic AKT3 pathogenic variants
Martina De Bortoli | Marta Ivars | Nicole Revencu | Marie-Cécile Nassogne | Cinzia Lavarino | Sonia Paco | Martin Lammens | Anne Renders | Dana Dumitriu | Raphaël Helaers | Laurence M. Boon | Eulalia Baselga | Miikka Vikkula
Targeted treatment in complex lymphatic anomaly: a case of synergistic efficacy of trametinib and sirolimus
Emmanuel Seront, Antoine Froidure, Nicole Revencu, Valerie Dekeuleneer, Philippe Clapuyt, Dana Dumitriu, Miikka Vikkula and Laurence M. Boon
Yoda1 opens the lymphatic path for craniosynostosis therapy
Aleksanteri Aspelund, Kari Alitalo
Preliminary results of the European multicentric phase III trial regarding sirolimus in slow-flow vascular malformations
Emmanuel Seront, … , Miikka Vikkula, Laurence M. Boon
Angiogenesis and Lymphangiogenesis in Medulloblastoma Development
Manon Penco-Campillo, Gilles Pages and Sonia Martial
Loss-of-function mutations of the TIE1 receptor tyrosine kinase cause late-onset primary lymphedema
Pascal Brouillard, … , Kari Alitalo, Miikka Vikkula
Lessons of Vascular Specialization From Secondary Lymphoid Organ Lymphatic Endothelial Cells
Silvia Arroz-Madeira, Tove Bekkhus, Maria H. Ulvmar, Tatiana V. Petrova
Mechanosensitive mTORC1 signaling maintains lymphatic valves
Cansaran Saygili Demir, Amelie Sabine, Muyun Gong, Olivier Dormond, and Tatiana V. Petrova
Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance
Sinem Karaman, Satu Paavonsalo, Krista Heinolainen, Madeleine H. Lackman, Amanda Ranta, Karthik A. Hemanthakumar, Yoshiaki Kubota4, and Kari Alitalo
Single and combined impacts of irradiation and surgery on lymphatic vasculature and brosis associated to secondary lymphedema
F. Buntinx, A. Lebeau, L. Gillot, L. Baudin, R. Ndong Penda, F. Morfoisse, F. Lallemand, G. Vottero, C. Nizet, J. L. Nizet, S. Blacher1 and A. Noel
Mechanisms and functions of intestinal vascular specialization
Jeremiah Bernier-Latmani, Alejandra Gonzalez-Loyola, and Tatiana V. Petrova
Somatic Loss-of-Function PIK3R1 and Activating Non-hotspot PIK3CA Mutations Associated with Capillary Malformation with Dilated Veins (CMDV)
Martina De Bortoli, Angela Queisser, Van Cuong Pham, Anne Dompmartin, Raphael Helaers, Simon Boutry, Cathy Claus, An-Katrien De Roo, Frank Hammer, Pascal Brouillard, Salim Abdelilah-Seyfried, Laurence M. Boon and Miikka Vikkula
15-Lipoxygenase promotes resolution of inflammation in lymphedema by controlling Treg cell function through IFN-β
A. Zamora, M. Nougué, L. Verdu, E. Balzan, T. Draia-Nicolau, E. Benuzzi,
F. Pujol, V. Baillif, E. Lacazette, F. Morfoisse, J. Galitzky, A. Bouloumié, M. Dubourdeau, B. Chaput, N. Fazilleau, J. Malloizel-Delaunay,
A. Bura-Rivière, A. C. Prats & B. Garmy-Susini
Apelin-VEGF-C mRNA delivery as therapeutic for the treatment of secondary lymphedema
Justine Creff , Asalaa Lamaa, Emeline Benuzzi, Elisa Balzan, Francoise Pujol, Tangra Draia-Nicolau, Manon Nougué, Lena Verdu, Florent Morfoisse, Eric Lacazette, Philippe Valet, Benoit Chaput, Fabian Gross, Regis Gayon, Pascale Bouillé, Julie Malloizel-Delaunay, Alessandra Bura-Rivière, Anne-Catherine Prats and Barbara Garmi-Susini
Targeting of the ELR+CXCL/CXCR1/2 Pathway Is a Relevant Strategy for the Treatment of Paediatric Medulloblastomas
Manon Penco-Campillo, Clément Molina, Patricia Piris, Nouha Soufi, Manon Carré, Marina Pagnuzzi-Boncompagni, Vincent Picco, Maeva Dufies, Cyril Ronco, Rachid Benhida, Sonia Martial, and Gilles Pagès
Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression
Emilia A. Korhonen, Aino Murtomäki, Sawan Kumar Jha, Andrey Anisimov, Anne Pink, Yan Zhang, Simon Stritt, Inam Liaqat, Lukas Stanczuk, Laura Alderfer, Zhiliang Sun, Emmi Kapiainen, Abhishek Singh, Ibrahim Sultan, Anni Lantta, Veli-Matti Leppänen, Lauri Eklund, Yulong He, Hellmut G. Augustin, Kari Vaahtomeri, Pipsa Saharinen, Taija Mäkinen, and Kari Alitalo
The Impact of Estrogen Receptor in Arterial and Lymphatic Vascular Diseases
Fontaine et al.
VEGFC negatively regulates the growth and aggressiveness of medulloblastoma cells
Penco-Campillo M et al.
Sex Hormones in Lymphedema
Morfoisse F et al.
Lymphedema alters lipolytic, lipogenic, immune and angiogenic properties of adipose tissue: a hypothesis‑generating study in breast cancer survivors
Doc M et al.
Coordinating effect of VEGFC and Oleic Acid promotes tumor lymphangiogenesis
Florent Morfoisse, Fabienne De Toni, Jeremy Nigri, Mohsen Hosseini, Audrey Zamora, Florence Tatin, Françoise Pujol, Jean-Emmanuel Sarry, Dominique Langin, Eric Lacazette, Anne-Catherine Prats, Richard Tomasini, Jean Galitzky, Anne Bouloumié, Barbara Garmy-Susini
Characterization of ANGPT2 mutations associated with primary lymphedema
Leppänen VM, Brouillard P, Korhonen EA, Sipilä T, Jha SK, Revencu N, Labarque V, Fastré E, Schlögel M, Ravoet M, Singer A, Luzzatto C, Angelone D, Crichiutti G, D’Elia A, Kuurne J, Elamaa H, Koh GY, Saharinen P, Vikkula M, Alitalo K
Lymphatic malformations: genetics, mechanisms and therapeutic strategies
Taija Mäkinen, Laurence M. Boon, Miikka Vikkula, Kari Alitalo
Development and aging of the lymphatic vascular system
Alejandra González-Loyola, Tatiana V. Petrova